transcription factor HES-3 (hairy & enhancer of split 3)

Function: - transcriptional repressor of genes that require a bHLH protein for their transcription - transcription repression requires formation of complex with corepressor protein (Groucho) Structure: - has a particular type of basic domain (presence of a helix- interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) - C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins - contains 1 basic helix-loop-helix (bHLH) domain - contains 1 Orange domain Compartment: nucleus

General

hairy & enhancer of split (HES) transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 20 kD entity length = 186 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 1-6 helix-loop-helix NAME: helix-loop-helix SITE: 7-50 FOR-BINDING-VIA: helix-loop-helix Orange {65-99} proline-rich region SITE: 111-170 MOTIF: proline residue (SEVERAL) WRPW {175-178}

Database Correlations

UniProt Q5TGS1 Pfam PF00010

References

UniProt :accession Q5TGS1