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transcription factor ETV7; transcription factor Tel-2; ETS-related protein Tel2; Tel-related Ets factor (ETV7, TEL2, TELB, TREF)
Function:
1) transcriptional repressor
2) binds to the DNA sequence 5'-CCGGAAGT-3'
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment: nucleus
Alternative splicing:
- named isoforms=8; A-H
- isoform A & isoform C do not seem to have repressor activity
Expression:
- expressed in hematopoietic tissues
General
Ets family protein
Properties
SIZE: MW = 39 kD
entity length = 341 aa
COMPARTMENT: cell nucleus
MOTIF: PNT {31-117}
ETS domain
NAME: ETS domain
SITE: 224-305
Database Correlations
OMIM 605255
UniProt Q9Y603
PFAM correlations
Entrez Gene 51513
Kegg hsa:51513
References
UniProt :accession Q9Y603