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transcription factor Dp-2; E2F dimerization partner 2 (TFDP2, DP2)
Function:
- can stimulate E2F-dependent transcription
- binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
- component of the DP2/E3F complex
- interacts with GMCL (putative)
- component of the DREAM complex
Structure: belongs to the E2F/DP family
Compartment: nucleus
Alternative splicing:
- named isoforms=4
- additional isoforms seem to exist
Expression:
- high levels in heart & skeletal muscle
- also found in placenta, kidney, brain, lung & liver.
- presence as well as the abundance of the different transcripts appear to vary significantly in different tissues & cell lines
General
DNA-binding protein
transcription factor (TF)
Properties
SIZE: entity length = 446 aa
MW = 49 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S24}
Ser phosphorylation site {S42}
nuclear translocation signal {103-118}
DNA-binding motif
SITE: 129-210
MOTIF: DEF box {176-210}
Dimerization {219-292}
MOTIF: DCB1 {229-261}
DCB2 {274-330}
acidic region {432-446}
MOTIF: acidic residue (SEVERAL)
References
- UniProt :accession Q14188
- Entrez Gene :accession 7029
Component-of
DREAM complex (LINC complex)
Databases & Figures
OMIM 602160
UniProt Q14188
PFAM correlations
Entrez Gene 7029
Kegg hsa:7029
Figures/diagrams/slides/tables related to transcription factor Dp-2