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transcription factor AP-2 epsilon (AP2-epsilon, activating enhancer-binding protein 2 epsilon, TFAP2E)
Function:
- activating protein 2 (transcription factor AP2)
- AP-2 epsilon may play a role in the development of the CNS & in cartilage differentiation (putative)
- binds DNA as a dimer
- can form homodimers or heterodimers with other AP-2 family members (putative)
Structure: belongs to the AP-2 family
Compartment: nucleus (putative)
Expression:
- expressed in skin, primary keratinocytes, immortalized keratinocytes, & HeLa cells
General
activating protein 2 (AP2)
phosphoprotein
Properties
SIZE: entity length = 442 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 22-122
MOTIF: proline residue (SEVERAL)
WW-binding {54-59}
DNA-binding motif
Ser phosphorylation site {S246}
helix-span-helix {287-417}
Database Correlations
UniProt Q6VUC0
Pfam PF03299
References
- UniProt :accession Q6VUC0
- Wikipedia; Note=Activatin protein 2 entry;
http://en.wikipedia.org/wiki/Activating_protein_2