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transcription factor AP-4; activating enhancer-binding protein 4; class C basic helix-loop-helix protein 41; bHLHc41 (TFAP4, BHLHC41)
Function:
- transcription factor
- activates both viral & cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'
- efficient DNA binding requires dimerization with another bHLH protein
Structure:
- homodimer
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
General
basic helix loop helix (bHLH) family transcription factor
phosphoprotein
Properties
SIZE: entity length = 338 aa
MW = 39 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 48-60
helix-loop-helix
NAME: helix-loop-helix
SITE: 61-100
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
SITE: 99-120
FOR-BINDING-VIA: leucine zipper
Ser phosphorylation site {S124}
Ser phosphorylation site {S139}
leucine zipper
SITE: 151-179
FOR-BINDING-VIA: leucine zipper
glutamine-rich region {193-222}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 225-244
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 600743
UniProt Q01664
Pfam PF00010
Entrez Gene 7023
Kegg hsa:7023
References
UniProt :accession Q01664