transcription factor 7-like 1 (HMG box transcription factor 3, TCF-3, TCF7L1, TCF3)

Function: 1) participates in the Wnt signaling pathway 2) binds to DNA & acts as a repressor in the absence of CTNNB1, & as an activator in its presence 3) necessary for terminal differentiation of epidermal cells, formation of keratohyalin granules & the development of barrier function of epidermis 4) down-regulates NQO1, leading to increased mitomycin C resistance 5) binds the armadillo repeat of CTNNB1 & forms a stable complex Structure: - belongs to the TCF/LEF family - contains 1 HMG box DNA-binding domain Compartment: nucleus Expression: - detected in hair follicles & skin keratinocytes, & at lower levels in stomach epithelium - putative Groucho interaction domain between the N-terminal CTNNB1 binding domain & the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 & CTNNB1

Properties

SIZE: MW = 63 kD entity length = 588 aa COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-74 FOR-BINDING-OF: beta catenin MOTIF: glycine-rich region {5-29} proline-rich region SITE: 117-326 MOTIF: proline residue (SEVERAL) HMG box SITE: 346-414 nuclear translocation signal {421-427}

Database Correlations

OMIM 604652 UniProt Q9HCS4 PFAM correlations

References

UniProt :accession Q9HCS4