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transcription factor 21; podocyte-expressed 1; epicardin; capsulin; Pod-1 (TCF21, POD1)
Function:
- role in epithelial-mesenchymal interactions in kidney & lung morphogenesis that include epithelial differentiation & branching morphogenesis
- may play a role in the specification or differentiation of one or more subsets of epicardial cell types
- efficient DNA binding requires dimerization with another bHLH protein
- forms a heterodimer with TCF3 & binds the E box (5'-CANNTG-3')
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 179 aa
MW = 20 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 80-91
helix-loop-helix
NAME: helix-loop-helix
SITE: 92-132
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 603306
UniProt O43680
Pfam PF00010
Entrez Gene 6943
Kegg hsa:6943
References
- UniProt :accession O43680
- Entrez Gene :accession 6943