transcription factor 20 (stromelysin 1 PDGF-responsive element-binding protein, SPRE-binding protein, nuclear factor SPBP, AR1, TCF20, KIAA0292, SPBP)

Function: 1) transcriptional activator/coactivator 2) binds to regulatory region of MMP3, thus controls stromelysin expression 3) stimulates activity of various transcriptional activators, including JUN, SP1, PAX6 & ETS1, thus a coactivator 4) interacts with RNF4 & JUN Structure: - homodimer - contains 1 A.T hook DNA-binding domain - contains 1 PHD-type zinc finger - atypical PHD domain functions as a negative modulator of cofactor binding Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in most tissues, except in ovary & prostate - isoform 1 is exclusively expressed in brain, heart & testis - predominates in liver & kidney - isoform 2 predominates in lung

General

phosphoprotein transcription factor (TF) zinc finger protein

Properties

SIZE: MW = 212 kD entity length = 1960 aa COMPARTMENT: cell nucleus MOTIF: alanine-rich region {62-70} MOTIF: alanine residue (SEVERAL) glutamine-rich region {174-182} MOTIF: glutamine residue (SEVERAL) serine-rich region {203-262} MOTIF: serine residue (SEVERAL) glutamine-rich region {310-322} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S538} Tyr phosphorylation site {Y548} Ser phosphorylation site {S559} Ser phosphorylation site {S574} Ser phosphorylation site {S583} leucine zipper SITE: 1170-1191 FOR-BINDING-VIA: leucine zipper nuclear translocation signal {1254-1268} A+T hook SITE: 1537-1551 proline-rich region SITE: 1556-1564 MOTIF: proline residue (SEVERAL) nuclear translocation signal {1576-1600} Thr phosphorylation site {T1671} nuclear translocation signal {1785-1792} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1884-1935 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 603107 UniProt Q9UGU0

References

UniProt :accession Q9UGU0