transcriptional enhancer factor TEF-1; TEA domain family member 1; TEAD-1; protein GT-IIC; transcription factor 13; NTEF-1 (TEAD1 TCF13 TEF1)

Function: - binds specifically & cooperatively to the SPH & GT-IIC enhancers (5'-GTGGAATGT-3') & activates transcription in vivo in a cell-specific manner - the activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor - involved in cardiac development - binds to the M-CAT motif Structure: contains 1 TEA DNA-binding domain Compartment: nucleus Expression: - preferentially expressed in skeletal muscle - lower levels in pancreas, placenta, & heart Pathology: - defects in TEAD1 are the cause of - Sveinsson chorioretinal atrophy

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 426 aa MW = 48 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S7} Ser phosphorylation site {S9} Ser phosphorylation site {S11} TEA domain SITE: 30-97 basic region {55-121} proline-rich region SITE: 143-204 MOTIF: proline residue (SEVERAL) transcriptional activation domain SITE: 167-426 MOTIF: calponin homology domain NAME: calponin homology domain SITE: 306-328

Database Correlations

OMIM correlations MORBIDMAP 189967 UniProt P28347 Pfam PF01285 Kegg hsa:7003

References

UniProt :accession P28347