transcription elongation regulator 1; TATA box-binding protein-associated factor 2S; transcription factor CA150 (TCERG1, CA150, TAF2S)

Function: - transcription factor - binds RNA polymerase 2 & inhibits elongation of transcripts from target promoters - regulates transcription elongation (TATA box-dependent) - necessary for TAT-dependent activation of the HIV1 promoter - binds formin (putative) - binds RNA polymerase 2, HD & SF1 Structure: - the FF domains - bind the phosphorylated C-terminus of RNA polymerase 2 largest subunit - probably mediate interaction with HTATSF1 - preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5) - the WW domains bind Pro-rich domains - contains 6 FF domains - contains 3 WW domains Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - detected in brain neurons Pathology: - up-regulated in brain tissue from patients with Huntington disease

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 1098 aa MW = 124 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 32-132 MOTIF: proline residue (SEVERAL) WW domain (W/rsp5/WWP domain) {131-164} glutamine-rich region {169-258} MOTIF: glutamine residue (SEVERAL) coiled coil {184-244} threonine-rich region {260-331} MOTIF: threonine residue (SEVERAL) proline-rich region SITE: 328-378 MOTIF: proline residue (SEVERAL) WW domain (W/rsp5/WWP domain) {429-462} glutamate-rich region {454-515} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S481} Thr phosphorylation site {T489} WW domain (W/rsp5/WWP domain) {528-561} coiled coil {606-655} MOTIF: nuclear translocation signal {626-630} FF domain {661-709} FF domain {727-776} FF domain {794-843} coiled coil {844-906} FF domain {898-949} FF domain {956-1007} FF domain {1014-1074} proline-rich region SITE: 1083-1087 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 605409 UniProt O14776 PFAM correlations Entrez Gene 10915 Kegg hsa:10915

References

UniProt :accession O14776