transcription elongation factor A protein-like 1 (TCEA-like protein 1, transcription elongation factor S-II protein-like 1, nuclear phosphoprotein p21/SIIR, TCEAL1, SIIR)

Function: 1) transcriptional regulation (putative) 2) modulates various viral & cellular promoters - transcription from the FOS promoter is increased - Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed 3) phosphorylation of Ser-36 & Ser-37 implicated in transcriptional repression 4) does not bind DNA directly Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed, including heart, ovary, prostate, skeletal muscle > brain, placenta, testis, small intestine > lung, liver, spleen Pathology: - expressed in several cancer cell lines

General

phosphoprotein transcription elongation factor A protein-like (TCEA-like protein, transcription elongation factor S-II protein-like, TCEAL)

Properties

SIZE: MW = 18 kD entity length = 157 aa COMPARTMENT: cell nucleus MOTIF: arginine/serine-rich region (RS domain) {15-72} MOTIF: serine residue (SEVERAL) arginine residue (SEVERAL) Ser phosphorylation site {S31} Ser phosphorylation site {S32} Ser phosphorylation site {S36} Ser phosphorylation site {S37} Ser phosphorylation site {S41} Ser phosphorylation site {S42} Ser phosphorylation site {S47} Ser phosphorylation site {S48}

Database Correlations

OMIM 300237 UniProt Q15170 Pfam PF06137

References

UniProt :accession Q15170