transcription elongation factor A protein 3 (transcription elongation factor S-II protein 3, transcription elongation factor TFIIS.h, TCEA3 TFIISH)

Function: - facilitates RNA polymerase 2 transcription elongation past template-encoded arresting sites - these arresting sites trap a some of the elongating RNA polymerase, resulting in block of transcription - cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'terminus

General

DNA-binding protein transcription elongation factor zinc finger protein

Properties

SIZE: entity length = 348 aa MW = 39 kD COMPARTMENT: cell nucleus MOTIF: TFIIS N-terminal {5-82} serine-rich region {130-173} MOTIF: serine residue (SEVERAL) TFIIS central {187-303} Zinc finger NAME: Zinc finger SITE: 306-346 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 604128 UniProt O75764 PFAM correlations Kegg hsa:6920

References

UniProt :accession O75764