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transcriptional repressor scratch 1; Scratch homolog 1 zinc finger protein; SCRT; Scratch 1; hScrt (SCRT1)
Function:
- transcriptional repressor
- binds E-box motif CAGGTG
- can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation
Structure:
- the N-terminal non Zn+2-finger region mediates the repressor activity
- belongs to the snail C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: brain specific
General
C2H2 type zinc finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 348 aa
MW = 36 kD
COMPARTMENT: cell nucleus
MOTIF: SNAG domain {1-20}
Zn finger C2H2-type
SITE: 191-213
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 222-244
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 248-270
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 276-298
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 304-327
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 605858
UniProt Q9BWW7
Entrez Gene 83482
Kegg hsa:83482
References
UniProt :accession Q9BWW7