transcriptional regulator PINT87aa (LINC-PINT)

Function: - enhances binding of the PAF1 complex to target gene promoters - plays a role in negative regulation of transcription - may function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA polymerase II-induced mRNA elongation - inhibits FOXM1-mediated transcription of PHB2 - interacts with PAF1 complex member PAF1 - interacts with transcription factor FOXM1 Compartment: - nucleus Expression: - expressed in brain, liver, kidney & stomach with lower levels in breast, intestine, thyroid & pancreas Notes: - encoded by the circular form of the long non-coding RNA LINC-PINT - suppresses glioblastoma cell proliferation & shows decreased expression in glioblastomas compared to normal non-tumor brain tissue - induces growth inhibition & cellular sensescence & decreases mitophagy in hepatocellular carcinoma (HCC) cells with higher levels of expression in non-tumor tissue than in adjacent HCC tissue

Properties

SIZE: entity length = 87 aa MW = 10 kD COMPARTMENT: cell nucleus

References

UniProt :accession A0A455ZAR2 - UniProt PubMed refs - PMID: 33754036