transcriptional regulator Kaiso (zinc finger & BTB domain-containing protein 33, ZBTB33, KAISO, ZNF348)

Function: 1) transcriptional regulator with bimodal DNA-binding specificity 2) binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' 3) binds to the non-methylated consensus sequence 5'-CTGCNA-3' 4) recruits the N-CoR repressor complex to promote histone deacetylation & the formation of repressive chromatin structures in target gene promoters 5) repression of target genes of the Wnt signaling pathway ? 6) transcriptional activation of a subset of target genes by the recruitment of CTNND2 7) self-associates 8) interacts with CTNND2 9) interaction with CTNND1 inhibits binding to both methylated & non-methylated DNA 10) interacts with NCOR1 11) interaction with KPNA2/RCH1 may mediate nuclear import 12) induced in vascular endothelium by wounding - effect is potentiated by prior laminar shear stress, which enhances wound closure Structure: - contains 1 BTB domain (POZ domain) - contains 3 C2H2-type zinc fingers Compartment: nucleus, cytoplasm Expression: expressed in vascular endothelium

General

DNA-binding protein phosphoprotein transcription factor (TF) zinc finger protein

Properties

SIZE: MW = 74 kD entity length = 672 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Self-association {1-136} MOTIF: binding site SITE: 1-103 FOR-BINDING-OF: nuclear receptor corepressor 1 BTB domain {32-94} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 Tyr phosphorylation site {Y442} binding site SITE: 454-672 FOR-BINDING-OF: catenin delta-1 MOTIF: nuclear translocation signal {471-480} Zn finger C2H2-type SITE: 494-516 EFFECTOR-BOUND: Zn+2 DNA-binding motif SITE: 514-638 Zn finger C2H2-type SITE: 522-544 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 550-573 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 300329 UniProt Q86T24 PFAM correlations

References

UniProt :accession Q86T24