transcriptional-regulating factor 1 (transcriptional-regulating protein 132, zinc finger transcription factor TReP-132, zinc finger protein rapa, breast cancer anti-estrogen resistance 2, TRERF1, BCAR2, RAPA, TREP132)

Function: 1) activates transcription of CYP11A1 2) interaction with CREBBP & EP300 results in a synergistic transcriptional activation of CYP11A1 3) interacts with CREBBP & EP300 4) contains 3 C2H2-type zinc fingers - contains 1 ELM2 domain - contains 1 Myb DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - expressed in thymus, testis, adrenal cortex > a drenal medulla, thyroid, stomach - expressed in steroidogenic JEG-3 & MCF-7 cells > non-steroidogenic HepG2 & HK293 cells

General

DNA-binding protein phosphoprotein zinc finger protein

Properties

SIZE: MW = 132 kD entity length = 1200 aa COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {202-417} MOTIF: glutamine residue (SEVERAL) CREBBP interaction {439-1200} MOTIF: Ser phosphorylation site {S491} Zn finger C2H2-type SITE: 512-534 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 553-749 MOTIF: proline residue (SEVERAL) ELM2 {779-870} DNA-binding motif SITE: 887-932 glutamate-rich region {956-982} MOTIF: glutamate residue (SEVERAL) Zn finger C2H2-type SITE: 1013-1037 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1086-1108 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q96PN7 PFAM correlations

References

UniProt :accession Q96PN7