transcriptional adapter 2-like; ADA2-like protein (TADA2L, TADA2A)

Function: 1) binds double-stranded DNA 2) binds dinucleosomes at the linker region between neighboring nucleosomes (putative) 3) chromatin remodeling (putative) 4) function of some acidic activation domains, which activate transcription from a distant site 5) interacts with GCN5 & NR3C1 6) associated with the P/CAF protein in the PCAF complex 7) component of the PCAF complex - associated with the P/CAF protein in the PCAF complex Structure: - contains 1 SANT domain - contains 1 SWIRM domain Compartment: nucleus Expression: - expressed in all tissues - most abundant in testis

Properties

SIZE: MW = 51 kD entity length = 443 aa COMPARTMENT: cell nucleus MOTIF: cysteine-rich region {17-45} SANT {70-122} SWIRM {356-443} MOTIF: DNA-binding motif SITE: 426-435

Database Correlations

OMIM 602276 UniProt O75478 PFAM correlations

References

UniProt :accession O75478