transcriptional activator protein Pur-beta (purine-rich element-binding protein B, PURB)

Function: 1) binds repeated elements in single-stranded DNA, i.e. purine-rich single strand of the PUR element located upstream of the MYC gene 2) role in control of vascular smooth muscle alpha-actin gene transcription as repressor in myoblasts & fibroblasts 3) role in transcriptional & translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory element 4) modulates constitutive liver galectin-3 gene transcription by binding to its promoter 5) role in dendritic transport of a subset of mRNAs Structure: - homodimer - heterodimer with PURA - heterotrimer with PURA & YBX1/Y-box protein 1 - belongs to the PUR DNA-binding protein family Compartment: nucleus Pathology: - expressed in myocardium of heart failure patients - defects in PURB may be a cause of progression of myelodysplastic syndrome towards acute myelogenous leukemia

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 33 kD entity length = 311 aa COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl Ser phosphorylation site {S5} Ser phosphorylation site {S7} DNA-binding motif SITE: 27-253 MOTIF: glycine-rich region {152-221} Ser phosphorylation site {S303}

Database Correlations

OMIM 608887 UniProt Q96QR8 Pfam PF04845

References

UniProt :accession Q96QR8