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transcriptional activator protein Pur-alpha (purine-rich single-stranded DNA-binding protein alpha, PURA, PUR1)
Function:
1) transcription activator (putative)
2) binds purine-rich single strand of the PUR element located upstream of the MYC gene
3) initiation of DNA replication
4) recombination
5) homodimer, heterodimer with PURB & heterotrimer with PURB & YBX1/Y-box protein 1
6) antagonizes action of MYEF2
Compartment: nucleus
General
transcription factor (TF)
Properties
SIZE: MW = 35 kD
entity length = 322 aa
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {11-53}
glutamate-rich region {293-322}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 600473
UniProt Q00577
Pfam PF04845
References
UniProt :accession Q00577