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TRAMP-like complex
Function:
- ATP-dependent exosome regulatory complex
Structure:
- subunits include:
- KIV2L2/MTR4 (a helicase)
- PAPD5 or PAPD7 (an oligadenylate polymerase)
- ZCCHC7 or ZCCHC8 (a substrate specific RNA-binding factor)
Compartment:
- nucleus, nucleolus
Related
Tramp
General
molecular complex
Properties
SUBUNITS: KIV2L2
PAP-associated domain-containing protein 5
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: serine-rich region {45-76}
MOTIF: serine residue (SEVERAL)
manganese [Mn]-binding site
SITE: 177-177
manganese [Mn]-binding site
SITE: 179-179
PAP-associated {308-368}
serine-rich region {447-525}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S484}
zinc finger CCHC domain-containing protein 7
MOTIF: serine-rich region {61-66}
MOTIF: serine residue (SEVERAL)
glutamate-rich region {160-163}
MOTIF: glutamate residue (SEVERAL)
Zn finger C2HC-type
SITE: 240-257
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 262-279
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 303-320
EFFECTOR-BOUND: Zn+2
Zn finger C2HC-type
SITE: 347-364
EFFECTOR-BOUND: Zn+2
References
UniProt :accession Q8NDF8
Components
PAP-associated domain-containing protein 5; topoisomerase-related function protein 4-2; TRF4-2 (PAPD5)
zinc finger CCHC domain-containing protein 7 (ZCCHC7)