trafficking protein particle complex subunit 2 protein TRAPPC2P1; MBP-1-interacting protein 2A; MIP-2A (TRAPPC2P1, SEDLP1, TRAPPC219)

Function: - prevents transcriptional repression & induction of cell death by ENO1 - may play a role in vesicular transport from endoplasmic reticulum to Golgi - interacts with PITX1, SF1, & TRAPPC3 (putative) - can homodimerize (putative) - part of the multisubunit TRAPP complex - interacts with ENO1 & TRAPPC2L Structure: - belongs to the TRAPP small subunits family, Sedlin subfamily Compartment: - nucleus (putative). cytoplasm, - perinuclear region - endoplasmic reticulum, Golgi - localized in perinuclear granular structures Expression: - expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta & lymphocytes Note: - the gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2 - the site of integration of this retrotransposed cDNA ppears to lie within an intron of the ZNF547 gene, which provides a promoter & non-coding 5' exon - TRAPPC2 & this protein are indistinguishable at protein level, & both proteins have been identified & functionally characterized

General

nuclear protein protein subunit

Properties

SIZE: entity length = 140 aa MW = 16 kD COMPARTMENT: cytoplasm cell nucleus golgi endoplasmic reticulum

Database Correlations

UniProt P0DI82 Pfam PF04628 Entrez Gene 6399

References

UniProt :accession P0DI82