TRAF3-interacting protein 1 (microtubule-interacting protein associated with TRAF3, MIP-T3, interleukin 13 receptor alpha 1-binding protein 1, TRAF3IP1, MIPT3)

Function: - inhibitory role on IL13 signaling by binding to IL13RA1 - involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity & DNA-binding - recruits TRAF3 & DISC1 to the microtubules - interacts with IL13RA1 - binds to microtubules, TRAF3 & DISC1 Structure: belongs to the TRAF3IP1 family Compartment: - cytoplasm, cytoskeleton, microtubules Alternative splicing: named isoforms=2 Expression: ubiquitous

General

microtubule-associated protein (MAP) phosphoprotein

Properties

SIZE: entity length = 691 aa MW = 79 kD COMPARTMENT: cytoplasm MOTIF: binding site SITE: 1-323 FOR-BINDING-OF: ABOLISHES MICROTUBULES MOTIF: arginine-rich region {211-281} MOTIF: arginine residue (SEVERAL) DISC1-interaction {223-691} MOTIF: Ser phosphorylation site {S476} coiled coil {571-666}

Database Correlations

OMIM 607380 UniProt Q8TDR0

References

UniProt :accession Q8TDR0