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trace amine-associated receptor 6; TAAR6; trace amine receptor 4; TaR-4
Function:
- orphan receptor
- ligands are trace amines
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: integral membrane protein. Expresseion:
expressed in
1) fetal liver
2) brain
a) hippocampus
b) amygdala
c) substantia nigra
d) frontal cortex
e) basal ganglia
General
glycoprotein
trace amine-associated receptor (TAAR)
Properties
SIZE: MW = 38 kD
entity length = 345 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-32}
MOTIF: N-glycosylation site {N4}
N-glycosylation site {N19}
transmembrane domain {33-53}
cytoplasmic loop {54-68}
transmembrane domain {69-89}
exoplasmic loop {90-107}
MOTIF: cysteine residue {C105}
MODIFICATION: cysteine residue {C190}
transmembrane domain {108-128}
cytoplasmic loop {129-147}
transmembrane domain {148-168}
exoplasmic loop {169-202}
MOTIF: cysteine residue {C190}
MODIFICATION: cysteine residue {C105}
transmembrane domain {203-223}
cytoplasmic loop {224-259}
transmembrane domain {260-276}
exoplasmic loop {277-282}
transmembrane domain {283-302}
cytoplasmic domain {303-345}
Database Correlations
OMIM 608923
UniProt Q96RI8
Pfam PF00001
Kegg hsa:3191
References
UniProt :accession Q96RI8