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trace amine-associated receptor 5 (TAAR5)
Function:
- orphan receptor
- ligands are likely small molecules
a) indolamines (5-methoxytryptamine)
b) phenylethylamines (phenylethanolamine)
c) amine neurotransmitters (trace amines)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: integral membrane protein
Expression:
expressed in
1) skeletal muscle
2) brain
a) amygdala
b) hippocampus
c) caudate nucleus
d) thalamus
e) hypothalamus
f) substantia nigra (weak expression)
General
glycoprotein
trace amine-associated receptor (TAAR)
Properties
SIZE: MW = 38 kD
entity length = 337 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-34}
MOTIF: N-glycosylation site {N21}
transmembrane domain {35-55}
cytoplasmic loop {56-70}
transmembrane domain {71-91}
exoplasmic loop {92-109}
MOTIF: cysteine residue {C99}
MODIFICATION: cysteine residue {C192}
transmembrane domain {110-130}
cytoplasmic loop {131-154}
transmembrane domain {155-175}
exoplasmic loop {176-204}
MOTIF: cysteine residue {C192}
MODIFICATION: cysteine residue {C99}
transmembrane domain {205-225}
cytoplasmic loop {226-253}
transmembrane domain {254-274}
exoplasmic loop {275-284}
transmembrane domain {285-307}
cytoplasmic domain {308-337}
Database Correlations
OMIM 607405
UniProt O14804
Pfam PF00001
Kegg hsa:9038
References
UniProt :accession O14804