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trace amine-associated receptor 1 (TAAR1, trace amine receptor 1, TaR-1)
Function:
1) receptor for trace amines
a) beta-phenylethylamine
b) p-tyramine
c) octopamine
d) tryptamine.
2) activates Gs-proteins which activate adenylate cyclase
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- integral membrane protein
Expression:
1) central nervous system
a) amydala
b) cerebellum
c) hippocampus
d) hypothalamus
e) medulla
f) pontine reticular formation
g) pituitary
2) peripheral nervous system
- dorsal root ganglia
3) stomach
4) kidney
5) lung
6) small intestine
7) liver
8) pancreas
9) prostate
10) spleen
Pathology:
- may be target for development of drugs to treat schizophrenia [2]
General
glycoprotein
trace amine-associated receptor (TAAR)
Properties
SIZE: MW = 39 kD
entity length = 339 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-25}
MOTIF: N-glycosylation site {N10}
N-glycosylation site {N17}
transmembrane domain {26-46}
cytoplasmic loop {47-59}
transmembrane domain {60-80}
exoplasmic loop {81-98}
MOTIF: cysteine residue {C96}
MODIFICATION: cysteine residue {C182}
transmembrane domain {99-119}
cytoplasmic loop {120-136}
transmembrane domain {137-157}
exoplasmic loop {158-188}
MOTIF: cysteine residue {C182}
MODIFICATION: cysteine residue {C96}
transmembrane domain {189-209}
cytoplasmic loop {210-252}
transmembrane domain {253-273}
exoplasmic loop {274-287}
transmembrane domain {288-308}
cytoplasmic domain {309-339}
Database Correlations
OMIM 609333
UniProt Q96RJ0
Pfam PF00001
Kegg hsa:1348
References
- UniProt :accession Q96RJ0
- Goff DC
The Pharmacologic Treatment of Schizophrenia - 2021.
JAMA. Published online December 28, 2020.
PMID: 33369626
https://jamanetwork.com/journals/jama/fullarticle/2774656