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trabectedin (Yondelis)
Indications:
- orphan drug status for treatment of soft tissue sarcoma
- treatment of ovarian cancer
* avoid; no tangible efficacy [3]
Adverse effects:
- diarrhea [3]
- hepatotoxicity [3]
Mechanism of action:
- interferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks & blocks the cell cycle in the G2 phase
General
antineoplastic agent (chemotherapeutic agent)
Database Correlations
PUBCHEM correlations
References
- Wikipedia: Trabectedin
http://en.wikipedia.org/wiki/Trabectedin)
- National Cancer Institute
http://www.cancer.gov/templates/drugdictionary.aspx?CdrID=42577
- Therapeutics Letter #108. Therapeutics Initiative
Drugs to Avoid.
http://www.ti.ubc.ca/2018/01/04/108-drugs-avoid/