nucleoprotein TPR (TPR)

Function: - component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import - its N-terminus is involved in activation of oncogenic kinases - role in the mitotic spindle checkpoint - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with MAD1L1 & MAD2L1 Compartment: - nucleus, nuclear pore complex - nuclear membrane - peripheral membrane protein, cytoplasmic side - detected at kinetochores during prometaphase Expression: - highest in testis, lung, thymus, spleen & brain - lower levels in heart, liver & kidney Pathology: - chromosomal rearrangements involving TPR are a cause of thyroid papillary carcinoma; intrachromosomal rearrangement that links the 5'-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1; TRK-T1 is a 55 kD protein reacting with antibodies against the carboxy terminus of the NTRK1 protein - involved in tumorigenic rearrangements with the MET or RAF genes

General

nuclear protein phosphoprotein proto oncogene protein

Properties

SIZE: entity length = 2363 aa MW = 267 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl coiled coil {29-370} MOTIF: breakpoint {191} Ser phosphorylation site {S379} Thr phosphorylation site {T381} coiled coil {423-602} MOTIF: serine-rich region {527-530} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S646} coiled coil {661-1173} MOTIF: Ser phosphorylation site {S920} Ser phosphorylation site {S1185} coiled coil {1215-1630} Thr phosphorylation site {T1677} Ser phosphorylation site {S1725} Ser phosphorylation site {S1804} glutamate-rich region {1833-1836} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S2034} Ser phosphorylation site {S2037} Ser phosphorylation site {S2048} Ser phosphorylation site {S2050} Ser phosphorylation site {S2073} Ser phosphorylation site {S2155} serine-rich region {2309-2312} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM correlations UniProt P12270 Pfam PF07926 Entrez Gene 7175 Kegg hsa:7175