tissue plasminogen activator inhibitor; tPA inhibitor (TPA-I)

Function: - complexes with catalytic site of urokinase or tissue-type plasminogen activator (tPA) to form inactive complex - inefficient when tPA is fibrin bound Note: - relationship to protein C inhibitor (SERPINA5) is unclear

Specific

plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1) plasminogen activator inhibitor 2; PAI-2; monocyte Arg-serpin; placental plasminogen activator inhibitor; Serpin B2; urokinase inhibitor (SERPINB2, PAI2, PLANH2)

General

plasma protein serine protease inhibitor; serpin

Properties

COMPARTMENT: plasma INHIBITS: serine protease SIZE: MW = 40 kD MOTIF: serpin motif SITE: C-TERMINAL FOR-BINDING-OF: serine protease MISC-INFO: CONCENTRATION 0.1-1.3 NM

References

Clinical Diagnosis & Management by Laboratory Methods, 18th ed, J.B. Henry (ed), W.B. Saunders, Philadelphia, PA, 1991 pg 739