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toxic oil syndrome
Incident described in Spain in 1981 associated with consumption of canola oil denatured with aniline. The oil was apparently meant for industrial use. The symptoms were similar to eosinophilia myalgia syndrome in the US, associated with consumption of a contaminate in L-tryptophan dietary supplements. Symptoms described at various stages include severe myalgias, eosinophilia, pulmonary hypertension, scleroderma, sicca syndrome, polyneuropathy, joint contractures and psychologic disturbances. Two compounds which may be connected with these two entities are 3-(phenylamino)-1,2-propanediol and 3-(phenylamino)alanine.
Related
eosinophilia-myalgia syndrome (EMS)
General
syndrome
toxicity; poisoning; overdose
References
- Mayeno AN et al
Biotransformation of 3-(phenylamino)-1,2-propanediol to
3-(phenylamino)alanine: a chemical link between toxic oil
syndrome and eosinophilia-myalgia syndrome.
Chem Res Toxicol 8(7):911-6, 1995 Oct-Nov
PMID: 8555405
- Mayeno AN et al
3-(Phenylamino)alanine, a novel aniline-derived amino
acid associated with the eosinophilia-myalgia syndrome:
a link to the toxic oil syndrome?
Mayo Clin Proc 67(12):1134-9, 1992 Dec
PMID: 1469924