toxic granulation

Etiology: 1) severe infection 2) other toxic conditions Pathology: - dark blue-purple (basophilic) cytoplasmic granules in metamyelocytes, bands or neutrophils - normally granules loose their basophilia in the mature neutrophil - the toxic granules stain peroxidase positive* * There may be less peroxidase activity in toxic neutrophils than in normal ones

General

abnormal morphologic structure (malformation) clinical hematology test

References

Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 667-68