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Torsin-1A-interacting protein 1 (TOR1AIP1)
Function:
- binds to A- & B-type lamins
- role in membrane attachment & assembly of the nuclear lamina
- interacts with TOR1A
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: belongs to the TOR1AIP family
Compartment: nucleus inner membrane
Alternative splicing: named isoforms=2
Related
torsin-1A; dystonia 1 protein; torsin family 1 member A (TOR1A, DQ2, DYT1)
General
membrane protein
nuclear protein
phosphoprotein
Properties
SIZE: MW = 66 kD
entity length = 583 aa
COMPARTMENT: cell nucleus
MOTIF: nuclear {1-338}
MOTIF: Ser phosphorylation site {S143}
Ser phosphorylation site {S154}
Ser phosphorylation site {S156}
Ser phosphorylation site {S163}
Ser phosphorylation site {S164}
Ser phosphorylation site {S169}
Thr phosphorylation site {T220}
Ser phosphorylation site {S266}
transmembrane domain {339-355}
coiled coil {359-435}
Database Correlations
UniProt Q5JTV8
Pfam PF05609
References
UniProt :accession Q5JTV8