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DNA topoisomerase I, mitochondrial; TOP1mt (TOP1MT)
Function:
- relieves DNA strain that arises during duplication of mitochondrial DNA
- ATP-independent breakage of single-stranded DNA, followed by passage & rejoining
Cofactor: divalent metal ions (Ca+2 or Mg+2)
Structure:
- belongs to the eukaryotic type 1 topoisomerase family
Compartment: mitochondria
Expression:
- ubiquitous
- highest in skeletal muscle, heart, brain & fetal liver
Notes:
- when a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a Tyr-oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand
General
mitochondrial protein
topoisomerase
Properties
SIZE: entity length = 601 aa
MW = 70 kD
COMPARTMENT: mitochondria
MOTIF: tyrosine residue {Y559}
Database Correlations
OMIM 606387
UniProt Q969P6
PFAM correlations
Entrez Gene 116447
Kegg hsa:116447
ENZYME 5.99.1.2
References
UniProt :accession Q969P6