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topoisomerase-1 inhibitor
Mechanism of action:
- antineoplastic agents that inhibit topoisomerase-1
- topoisomerase 1 acts as a positive regulator of RNA polymerase II transcriptional activity at pathogen- induced genes [1]
- suppresses host response against viral & bacterial antigens
Comparative biology:
- topoisomerase-1 inhibitor protected mice from death in experimental models of lethal inflammation [1]
Related
topoisomerase-1 (TOP1)
Specific
irinotecan; camptothecin (Camptosar, Topotecin, Onivyde, CPT-11)
topotecan (Hycamtin, SKF-104864A, Topo, TPT)
General
anti-inflammatory agent
topoisomerase inhibitor
References
- Rialdi A et al.
Topoisomerase 1 inhibition suppresses inflammatory genes and
protects from death by inflammation.
Science 2016 May 27; 352:aad7993
PMID: 27127234