Toll-like receptor 8; CD288 (TLR8)

Function: 1) innate immune response to microbial agents 2) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 3) binds MyD88 via their respective TIR domains Structure: - belongs to the Toll-like receptor family - contains 24 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: membrane Expression: - expressed in brain, heart, lung, liver, placenta - expressed in monocytes > in CD11c+ immature dendritic cells

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein leucine-rich repeat-containing protein (LRRC) toll-like receptor

Properties

SIZE: entity length = 1041 aa MW = 120 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} N-glycosylation site {N29} N-glycosylation site {N42} leucine-rich repeat SITE: 61-85 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N80} leucine-rich repeat SITE: 87-112 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N88} N-glycosylation site {N115} leucine-rich repeat SITE: 124-147 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N160} leucine-rich repeat SITE: 169-198 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 200-223 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 225-244 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 246-267 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N247} N-glycosylation site {N285} leucine-rich repeat SITE: 286-309 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N293} leucine-rich repeat SITE: 311-334 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 336-361 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N358} N-glycosylation site {N362} leucine-rich repeat SITE: 366-389 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 393-416 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N395} N-glycosylation site {N416} leucine-rich repeat SITE: 418-440 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N443} leucine-rich repeat SITE: 490-511 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N511} leucine-rich repeat SITE: 529-552 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N546} leucine-rich repeat SITE: 554-581 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N582} leucine-rich repeat SITE: 583-607 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N590} leucine-rich repeat SITE: 609-630 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 638-661 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N640} leucine-rich repeat SITE: 663-686 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N680} leucine-rich repeat SITE: 687-710 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 711-734 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 736-758 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N752} leucine-rich repeat SITE: 761-785 MOTIF: leucine residue (SEVERAL) transmembrane domain {828-848} TIR domain {878-1025}

Database Correlations

OMIM 300366 UniProt Q9NR97 PFAM correlations Entrez Gene 51311 Kegg hsa:5131