Toll-like receptor 7 (TLR7)

Function: 1) innate immune response to microbial agents 2) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 3) binds MyD88 via their respective TIR domains Structure: - belongs to the Toll-like receptor family - contains 27 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: membrane Expression: - expressed in brain, placenta, spleen, stomach, small intestine, lung, in plasmacytoid pre-dendritic cells Pathology: - gain of function in TLR7 implicated in systemic lupus erythematosus [3] Genetics: - X-chromosome linked

General

glycoprotein leucine-rich repeat-containing protein (LRRC) phosphoprotein toll-like receptor

Properties

SIZE: entity length = 1049 aa MW = 121 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} leucine-rich repeat SITE: 43-64 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 65-87 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N66} N-glycosylation site {N69} leucine-rich repeat SITE: 110-126 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 127-149 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 151-170 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N167} leucine-rich repeat SITE: 171-195 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N202} leucine-rich repeat SITE: 203-226 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N215} leucine-rich repeat SITE: 228-247 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 248-275 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 289-312 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 314-337 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 339-368 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N361} leucine-rich repeat SITE: 369-392 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 396-419 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N413} leucine-rich repeat SITE: 421-443 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N488} leucine-rich repeat SITE: 492-515 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 516-540 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N523} N-glycosylation site {N534} leucine-rich repeat SITE: 541-564 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 566-588 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N590} leucine-rich repeat SITE: 595-618 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 619-644 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 649-672 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 674-697 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N679} leucine-rich repeat SITE: 698-721 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N720} leucine-rich repeat SITE: 723-745 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 746-769 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 772-795 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N799} transmembrane domain {840-860} TIR domain {889-1036} MOTIF: Ser phosphorylation site {S1010}

Database Correlations

OMIM 300365 UniProt Q9NYK1 PFAM correlations Entrez Gene 51284 Kegg hsa:5128