Toll-like receptor 6; CD286 (TLR6)

Function: 1) innate immune response to Gram-positive bacteria & fungi 2) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 3) recognizes pathogen antigens cooperatively with TLR2 a) mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2) b) soluble tuberculosis factor (STF) c) phenol-soluble modulin (PSM) c) B. burgdorferi outer surface protein A lipoprotein (OspA-L) 4) binds TLR2 via their respective extracellular domains 5) binds MyD88 via their respective TIR domains Structure: - belongs to the Toll-like receptor family - contains 13 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: - cell membrane - cytoplasmic vesicle - phagosome membrane Expression: - expressed in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells, dermal microvessel endothelial cells

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein leucine-rich repeat-containing protein (LRRC) toll-like receptor

Properties

SIZE: entity length = 796 aa MW = 92 kD COMPARTMENT: cytoplasm cellular membrane MOTIF: signal sequence {1-31} leucine-rich repeat SITE: 51-74 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 75-98 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 100-120 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 121-144 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N144} leucine-rich repeat SITE: 158-175 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 176-201 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N186} N-glycosylation site {N214} leucine-rich repeat SITE: 222-248 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N253} N-glycosylation site {N285} N-glycosylation site {N359} leucine-rich repeat SITE: 376-400 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 402-428 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N423} leucine-rich repeat SITE: 430-447 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N434} leucine-rich repeat SITE: 449-472 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 474-496 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 498-517 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N583} transmembrane domain {587-607} TIR domain {640-784}

Database Correlations

OMIM 605403 UniProt Q9Y2C9 PFAM correlations Entrez Gene 10333 Kegg hsa:1033