Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3 (TLR5, TIL3)

Function: 1) innate immune response to microbial agents 2) mediates detection of bacterial flagellins 3) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 4) binds MyD88 via their respective TIR domains Structure: - belongs to the Toll-like receptor family - contains 15 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: membrane Expression: - expressed in ovary, peripheral blood leukocytes, especially monocytes > CD11c+ immature dendritic cells, prostate, testis Polymorphism: - genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 - individuals with a stop codon polymorphism in position 392 are unable to mediate flagellin signaling a) expressed in dominant fashion b) associated with susceptibility to pneumonia caused by Legionella pneumophila Pharmacology: - TLR5 agonist CBLB502 may be useful as radioprotective agent during radiation therapy for cancer treatment

General

glycoprotein leucine-rich repeat-containing protein (LRRC) toll-like receptor

Properties

SIZE: entity length = 858 aa MW = 98 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} N-glycosylation site {N37} leucine-rich repeat SITE: 45-68 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N46} leucine-rich repeat SITE: 94-117 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 144-168 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 170-192 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N245} leucine-rich repeat SITE: 287-310 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 311-334 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 336-358 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N342} leucine-rich repeat SITE: 359-382 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 383-407 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 415-437 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N422} leucine-rich repeat SITE: 447-470 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 472-496 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 501-524 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 526-548 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 550-570 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N595} N-glycosylation site {N598} transmembrane domain {640-660} TIR domain {691-837}

Database Correlations

OMIM correlations MORBIDMAP 603031 UniProt O60602 PFAM correlations Entrez Gene 7100 Kegg hsa:7100