Toll-like receptor 10; CD290 (TLR10)

Function: 1) innate immune response to microbial agents 2) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 3) binds MyD88 via their respective TIR domains Structure: - belongs to the Toll-like receptor family - contains 15 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: membrane Expression: - expressed in spleen, lymph node, thymus, tonsil > lung - highly expressed in promyelocytic HL-60 cells & in B-cell lines

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein leucine-rich repeat-containing protein (LRRC) toll-like receptor

Properties

SIZE: entity length = 811 aa MW = 95 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} leucine-rich repeat SITE: 24-46 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N33} N-glycosylation site {N36} leucine-rich repeat SITE: 47-70 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 71-94 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 96-116 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 117-139 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N140} leucine-rich repeat SITE: 141-164 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N189} N-glycosylation site {N236} N-glycosylation site {N278} leucine-rich repeat SITE: 296-321 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 325-348 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N330} leucine-rich repeat SITE: 350-367 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 371-395 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 397-419 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N416} leucine-rich repeat SITE: 421-440 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N427} leucine-rich repeat SITE: 442-465 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 467-489 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 556-581 MOTIF: leucine residue (SEVERAL) transmembrane domain {577-597} TIR domain {632-778}

Database Correlations

OMIM 606270 UniProt Q9BXR5 PFAM correlations Entrez Gene 81793 Kegg hsa:8179