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tolloid-like protein 1 (TLL2, KIAA0932)
Function:
1) metalloprotease
2) specifically processes pro-lysyl oxidase
3) dorsal-ventral patterning & skeletogenesis during development
Cofactor: binds 1 Zn+2 per subunit
Compartment: secreted
General
glycoprotein
metalloprotease
Properties
SIZE: MW = 114 kD
entity length = 1015 aa
MOTIF: signal sequence {1-25}
Metalloprotease {150-350}
MOTIF: N-glycosylation site {N171}
Zn+2-binding site
SITE: 242-242
glutamate residue {E243}
Zn+2-binding site
SITE: 246-246
Zn+2-binding site
SITE: 252-252
CUB domain {351-463}
MOTIF: cysteine residue {C351}
MODIFICATION: cysteine residue {C377}
N-glycosylation site {N361}
cysteine residue {C377}
MODIFICATION: cysteine residue {C351}
N-glycosylation site {N392}
cysteine residue {C404}
MODIFICATION: cysteine residue {C426}
cysteine residue {C426}
MODIFICATION: cysteine residue {C404}
CUB domain {464-576}
MOTIF: cysteine residue {C464}
MODIFICATION: cysteine residue {C490}
cysteine residue {C490}
MODIFICATION: cysteine residue {C464}
cysteine residue {C517}
MODIFICATION: cysteine residue {C539}
cysteine residue {C539}
MODIFICATION: cysteine residue {C517}
EGF domain {576-617}
MOTIF: cysteine residue {C580}
MODIFICATION: cysteine residue {C592}
cysteine residue {C588}
MODIFICATION: cysteine residue {C601}
cysteine residue {C592}
MODIFICATION: cysteine residue {C580}
cysteine residue {C601}
MODIFICATION: cysteine residue {C588}
cysteine residue {C603}
MODIFICATION: cysteine residue {C616}
cysteine residue {C616}
MODIFICATION: cysteine residue {C603}
CUB domain {620-732}
MOTIF: cysteine residue {C620}
MODIFICATION: cysteine residue {C646}
N-glycosylation site {N628}
cysteine residue {C646}
MODIFICATION: cysteine residue {C620}
cysteine residue {C673}
MODIFICATION: cysteine residue {C695}
cysteine residue {C695}
MODIFICATION: cysteine residue {C673}
EGF domain {732-772}
MOTIF: cysteine residue {C736}
MODIFICATION: cysteine residue {C747}
cysteine residue {C743}
MODIFICATION: cysteine residue {C756}
cysteine residue {C747}
MODIFICATION: cysteine residue {C736}
cysteine residue {C756}
MODIFICATION: cysteine residue {C743}
cysteine residue {C758}
MODIFICATION: cysteine residue {C771}
cysteine residue {C771}
MODIFICATION: cysteine residue {C758}
CUB domain {776-888}
MOTIF: cysteine residue {C776}
MODIFICATION: cysteine residue {C802}
cysteine residue {C802}
MODIFICATION: cysteine residue {C776}
N-glycosylation site {N805}
cysteine residue {C829}
MODIFICATION: cysteine residue {C851}
cysteine residue {C851}
MODIFICATION: cysteine residue {C829}
CUB domain {889-1005}
MOTIF: cysteine residue {C889}
MODIFICATION: cysteine residue {C919}
cysteine residue {C919}
MODIFICATION: cysteine residue {C889}
cysteine residue {C946}
MODIFICATION: cysteine residue {C968}
cysteine residue {C968}
MODIFICATION: cysteine residue {C946}
Database Correlations
OMIM 606743
UniProt Q9Y6L7
PFAM correlations
References
UniProt :accession Q9Y6L7