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tolazoline (Priscoline, Arterodyl)

Tradename: Priscoline. Indications: - persistent fetal circulation Dosage: - load 1-2 mg/kg IV over 10 min, then - infusion 1-2 mg/kg/hr. Injection: 25 mg/mL (10 mL). Adverse effects: 1) common (> 10%) - GI bleeding, abdominal pain, hypochloremic acidosis, hypotension, acute renal failure, oliguria, thrombocytopenia, burning at site of injection 2) less common (1-10%) - nausea, diarrhea, increased pilomotor activity, peripheral vasodilation, tachycardia 3) uncommon (< 1%) - mydriasis, hypertension, tachycardia, arrhythmias, agranulocytosis, pancytopenia, increased secretions, pulmonary hemorrhage

Interactions

drug interactions drug adverse effects of antihypertensive agents

General

alpha adrenergic receptor antagonist imidazole; glyoxaline; 1,3-diazole; iminazole

Properties

MISC-INFO: elimination route LIVER pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998