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CD137; tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CDw137 (TNFRSF9, CD137, ILA)
Function:
- receptor for TNFSF14/4-1BBL
- possibly active during T cell activation
- interacts with TRAF1, TRAF2 & TRAF3
- interacts with LRR-repeat protein 1/LRR-1
Structure: contains 4 TNFR-cys repeats
Compartment: membrane
Expression: expressed on the surface of activated T-cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 255 aa
MW = 28 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
TNFR-Cys {24-45}
MOTIF: cysteine residue {C28}
MODIFICATION: cysteine residue {C37}
cysteine residue {C31}
MODIFICATION: cysteine residue {C45}
cysteine residue {C37}
MODIFICATION: cysteine residue {C28}
cysteine residue {C45}
MODIFICATION: cysteine residue {C31}
TNFR-Cys {47-86}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C62}
cysteine residue {C62}
MODIFICATION: cysteine residue {C48}
cysteine residue {C65}
MODIFICATION: cysteine residue {C78}
cysteine residue {C68}
MODIFICATION: cysteine residue {C86}
cysteine residue {C78}
MODIFICATION: cysteine residue {C65}
cysteine residue {C86}
MODIFICATION: cysteine residue {C68}
TNFR-Cys {87-118}
MOTIF: cysteine residue {C88}
MODIFICATION: cysteine residue {C94}
cysteine residue {C94}
MODIFICATION: cysteine residue {C88}
cysteine residue {C99}
MODIFICATION: cysteine residue {C106}
cysteine residue {C102}
MODIFICATION: cysteine residue {C117}
cysteine residue {C106}
MODIFICATION: cysteine residue {C99}
cysteine residue {C117}
MODIFICATION: cysteine residue {C102}
TNFR-Cys {119-159}
MOTIF: cysteine residue {C121}
MODIFICATION: cysteine residue {C133}
cysteine residue {C133}
MODIFICATION: cysteine residue {C121}
N-glycosylation site {N138}
cysteine residue {C139}
MODIFICATION: cysteine residue {C158}
N-glycosylation site {N149}
cysteine residue {C158}
MODIFICATION: cysteine residue {C139}
transmembrane domain {187-213}
LRR-1 interaction {214-255}
Database Correlations
OMIM 602250
UniProt Q07011
Pfam PF00020
Entrez Gene 3604
Kegg hsa:3604
References
- UniProt :accession Q07011
- NIEHS-SNPs
http://egp.gs.washington.edu/data/tnfrsf9/
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Smith CA, Davis T, Anderson D, Solam L, Beckmann MP,
Jerzy R, Dower SK, Cosman D, Goodwin RG.
A receptor for tumor necrosis factor defines an unusual family
of cellular and viral proteins.
Science. 1990 May 25;248(4958):1019-23.
PMID: 2160731
- OMIM :accession 602250