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tumor necrosis factor receptor superfamily member 6B; decoy receptor for Fas ligand; decoy receptor 3; DcR3; M68 (TNFRSF6B, DCR3, TR6, UNQ186/PRO212)
Function:
- decoy receptor for the cytotoxic ligands TNFS14/LIGHT & TNFSF6/FASL
- protects against apoptosis
Structure: contains 4 TNFR-cys repeats
Compartment: secreted
Expression:
- expressed in fetal lung, brain & liver
- expressed in adult stomach, spinal cord, lymph node, trachea, spleen, colon & lung
Pathology:
- highly expressed in several primary tumors from colon, stomach, rectum, esophagus & in SW480 colon carcinoma cells
General
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 300 aa
MW = 33 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-29}
TNFR-Cys {31-70}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C62}
cysteine residue {C52}
MODIFICATION: cysteine residue {C70}
cysteine residue {C62}
MODIFICATION: cysteine residue {C49}
cysteine residue {C70}
MODIFICATION: cysteine residue {C52}
TNFR-Cys {72-113}
MOTIF: cysteine residue {C73}
MODIFICATION: cysteine residue {C88}
cysteine residue {C88}
MODIFICATION: cysteine residue {C73}
cysteine residue {C91}
MODIFICATION: cysteine residue {C105}
cysteine residue {C95}
MODIFICATION: cysteine residue {C113}
cysteine residue {C105}
MODIFICATION: cysteine residue {C91}
cysteine residue {C113}
MODIFICATION: cysteine residue {C95}
TNFR-Cys {115-150}
MOTIF: cysteine residue {C115}
MODIFICATION: cysteine residue {C126}
cysteine residue {C126}
MODIFICATION: cysteine residue {C115}
cysteine residue {C132}
MODIFICATION: cysteine residue {C150}
cysteine residue {C150}
MODIFICATION: cysteine residue {C132}
TNFR-Cys {152-193}
MOTIF: cysteine residue {C153}
MODIFICATION: cysteine residue {C168}
cysteine residue {C168}
MODIFICATION: cysteine residue {C153}
N-glycosylation site {N173}
cysteine residue {C174}
MODIFICATION: cysteine residue {C193}
cysteine residue {C193}
MODIFICATION: cysteine residue {C174}
Database Correlations
OMIM 603361
UniProt O95407
Pfam PF00020
Entrez Gene 8771
Kegg hsa:8771
References
UniProt :accession O95407