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tumor necrosis factor receptor superfamily member 21; TNFR-related death receptor 6; Death receptor 6 (TNFRSF21 DR6 UNQ437/PRO868)
Function:
- may activate NF-kappa-B & JNK & promote apoptosis
- associates with TRADD
Structure:
- contains 1 death domain
- contains 4 TNFR-Cys repeats
Compartment: membrane
Expression:
- highly expressed in heart, brain, placenta, pancreas, lymph node, thymus & prostate
- detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow & fetal liver
- very low levels were found in adult liver & peripheral blood leukocytes
Note: uncertain whether Met-1 or Met-25 is the initiator
General
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 655 aa
MW = 72 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-41}
TNFR-Cys {50-88}
MOTIF: cysteine residue {C67}
MODIFICATION: cysteine residue {C80}
cysteine residue {C70}
MODIFICATION: cysteine residue {C88}
cysteine residue {C80}
MODIFICATION: cysteine residue {C67}
N-glycosylation site {N82}
cysteine residue {C88}
MODIFICATION: cysteine residue {C70}
TNFR-Cys {90-131}
MOTIF: cysteine residue {C91}
MODIFICATION: cysteine residue {C106}
cysteine residue {C106}
MODIFICATION: cysteine residue {C91}
cysteine residue {C109}
MODIFICATION: cysteine residue {C123}
cysteine residue {C113}
MODIFICATION: cysteine residue {C131}
cysteine residue {C123}
MODIFICATION: cysteine residue {C109}
cysteine residue {C131}
MODIFICATION: cysteine residue {C113}
TNFR-Cys {133-167}
MOTIF: cysteine residue {C133}
MODIFICATION: cysteine residue {C144}
N-glycosylation site {N141}
cysteine residue {C144}
MODIFICATION: cysteine residue {C133}
cysteine residue {C150}
MODIFICATION: cysteine residue {C168}
cysteine residue {C168}
MODIFICATION: cysteine residue {C150}
TNFR-Cys {170-211}
MOTIF: cysteine residue {C171}
MODIFICATION: cysteine residue {C186}
cysteine residue {C186}
MODIFICATION: cysteine residue {C171}
cysteine residue {C192}
MODIFICATION: cysteine residue {C211}
cysteine residue {C211}
MODIFICATION: cysteine residue {C192}
N-glycosylation site {N252}
N-glycosylation site {N257}
N-glycosylation site {N278}
N-glycosylation site {N289}
transmembrane domain {350-370}
death domain
NAME: death domain
SITE: 415-498
Database Correlations
OMIM 605732
UniProt O75509
Pfam PF00531
Entrez Gene 27242
Kegg hsa:2724
References
UniProt :accession O75509