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tumor necrosis factor receptor superfamily member 19L; receptor expressed in lymphoid tissues (RELT, TNFRSF19L)
Function:
- mediates activation of NF-kappa-B
- may play a role in T-cell activation
- associates with TRAF1
- interacts with RELL1, RELL2 & OXSR1
- phosphorylated in vitro by OXSR1
Structure:
- belongs to the RELT family
- contains 1 TNFR-Cys repeat
Compartment: cell membrane, cytoplasm
Expression:
- highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow & fetal liver
- very low levels in skeletal muscle, testis & colon
- not detected in brain, kidney & pancreas
General
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 430 aa
MW = 46 kD
COMPARTMENT: cytoplasm
cellular membrane
MOTIF: signal sequence {1-25}
TNFR-Cys {50-90}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C65}
cysteine residue {C65}
MODIFICATION: cysteine residue {C51}
cysteine residue {C71}
MODIFICATION: cysteine residue {C90}
cysteine residue {C90}
MODIFICATION: cysteine residue {C71}
N-glycosylation site {N149}
transmembrane domain {163-183}
Database Correlations
OMIM 611211
UniProt Q969Z4
Entrez Gene 84957
Kegg hsa:8495
References
UniProt :accession Q969Z4