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tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; activation-inducible TNFR family receptor (TNFRSF18, AITR, GITR, UNQ319/PRO364)
Function:
- receptor for TNFSF18
- seems to be involved in interactions between activated T-lymphocytes & endothelial cells & in the regulation of T-cell receptor-mediated cell death mediated NF-kappa-B activation via the TRAF2/NIK pathway
- binds to TRAF1, TRAF2, & TRAF3, but not TRAF5 & TRAF6
- binds through its C-terminus to SIVA1/SIVA
Structure: contains 3 TNFR-Cys repeats
Compartment:
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in lymph node, peripheral blood leukocytes &
- up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation
General
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 241 aa
MW = 26 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-25}
TNFR-Cys {34-72}
MOTIF: cysteine residue {C34}
MODIFICATION: cysteine residue {C49}
cysteine residue {C49}
MODIFICATION: cysteine residue {C34}
TNFR-Cys {74-112}
MOTIF: cysteine residue {C74}
MODIFICATION: cysteine residue {C86}
cysteine residue {C81}
MODIFICATION: cysteine residue {C94}
cysteine residue {C86}
MODIFICATION: cysteine residue {C74}
cysteine residue {C94}
MODIFICATION: cysteine residue {C81}
TNFR-Cys {115-153}
MOTIF: cysteine residue {C115}
MODIFICATION: cysteine residue {C134}
cysteine residue {C128}
MODIFICATION: cysteine residue {C153}
cysteine residue {C134}
MODIFICATION: cysteine residue {C115}
N-glycosylation site {N146}
cysteine residue {C153}
MODIFICATION: cysteine residue {C128}
transmembrane domain {163-183}
Database Correlations
OMIM 603905
UniProt Q9Y5U5
Entrez Gene 8784
Kegg hsa:8784
References
UniProt :accession Q9Y5U5