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tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; DcR1; Decoy TRAIL receptor without death domain; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; trail receptor without an intracellular domain; lymphocyte inhibitor of TRAIL; antagonist decoy receptor for TRAIL/apo-2L; CD263 (TNFRSF10C DCR1 LIT TRAILR3 TRID UNQ321/PRO366)
Function:
- receptor for the cytotoxic ligand TRAIL
- may protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 & R2 for binding to the ligand
Structure:
- N-glycosylated & O-glycosylated
- lacks a cytoplasmic death domain & thus is not capable of inducing apoptosis.
- contains 3 TNFR-cys repeats
Compartment: cell membrane; lipid-anchor, GPI-anchor
Expression:
- higher expression in normal tissues than in tumor cell lines
- highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung & heart
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: MW = 27 kD
entity length = 259 aa
COMPARTMENT: plasma membrane
MOTIF: TNFR/NGFR cysteine rich region {69-109}
MOTIF: cysteine residue {C69}
MODIFICATION: cysteine residue {C85}
N-glycosylation site {N77}
cysteine residue {C85}
MODIFICATION: cysteine residue {C69}
cysteine residue {C88}
MODIFICATION: cysteine residue {C101}
cysteine residue {C91}
MODIFICATION: cysteine residue {C109}
cysteine residue {C101}
MODIFICATION: cysteine residue {C88}
cysteine residue {C109}
MODIFICATION: cysteine residue {C91}
TNFR/NGFR cysteine rich region {110-149}
MOTIF: cysteine residue {C111}
MODIFICATION: cysteine residue {C125}
cysteine residue {C125}
MODIFICATION: cysteine residue {C111}
cysteine residue {C128}
MODIFICATION: cysteine residue {C141}
cysteine residue {C131}
MODIFICATION: cysteine residue {C149}
N-glycosylation site {N140}
cysteine residue {C141}
MODIFICATION: cysteine residue {C128}
cysteine residue {C149}
MODIFICATION: cysteine residue {C131}
N-glycosylation site {N156}
glycosyl phosphatidylinositol [GPI] membrane anchor {C-TERMINUS}
Database Correlations
OMIM 603613
UniProt O14798
Pfam PF00020
Entrez Gene 8794
Kegg hsa:8794
References
- UniProt :accession O14798
- OMIM :accession 603613
- Entrez Gene :accession 8794