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tissue factor pathway inhibitor 2; TFPI-2; placental protein 5; PP5 (TFPI2)
Function:
- may play a role in regulation of plasmin-mediated matrix remodeling
- inhibits trypsin, plasmin, factor VIIa/tissue factor & weakly factor Xa
- has no effect on thrombin
Structure:
- contains 3 BPTI/Kunitz inhibitor domains
Compartment: secreted
Expression:
- expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, & maternal serum near term
General
glycoprotein
placental protein
serine protease inhibitor; serpin
Properties
SIZE: entity length = 235 aa
MW = 27 kD
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: placenta
MOTIF: signal sequence {1-22}
BPTI/Kunitz inhibitor 1 {36-86}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C86}
cysteine residue {C45}
MODIFICATION: cysteine residue {C69}
peptide motif {46-47}
cysteine residue {C61}
MODIFICATION: cysteine residue {C82}
cysteine residue {C69}
MODIFICATION: cysteine residue {C45}
cysteine residue {C82}
MODIFICATION: cysteine residue {C61}
cysteine residue {C86}
MODIFICATION: cysteine residue {C36}
BPTI/Kunitz inhibitor 2 {96-149}
MOTIF: cysteine residue {C96}
MODIFICATION: cysteine residue {C149}
cysteine residue {C106}
MODIFICATION: cysteine residue {C130}
peptide motif {107-108}
N-glycosylation site {N116}
cysteine residue {C122}
MODIFICATION: cysteine residue {C145}
cysteine residue {C130}
MODIFICATION: cysteine residue {C106}
cysteine residue {C145}
MODIFICATION: cysteine residue {C122}
cysteine residue {C149}
MODIFICATION: cysteine residue {C96}
BPTI/Kunitz inhibitor 3 {158-208}
MOTIF: cysteine residue {C158}
MODIFICATION: cysteine residue {C208}
cysteine residue {C167}
MODIFICATION: cysteine residue {C191}
peptide motif {168-169}
N-glycosylation site {N170}
cysteine residue {C183}
MODIFICATION: cysteine residue {C204}
cysteine residue {C191}
MODIFICATION: cysteine residue {C167}
cysteine residue {C204}
MODIFICATION: cysteine residue {C183}
cysteine residue {C208}
MODIFICATION: cysteine residue {C158}
lysine-rich region {213-217}
MOTIF: lysine residue (SEVERAL)
INHIBITS: serine protease
Database Correlations
OMIM 600033
UniProt P48307
Pfam PF00014
Entrez Gene 7980
Kegg hsa:7980