Search
Tissue factor pathway inhibitor; TFPI; extrinsic pathway inhibitor; EPI; lipoprotein-associated coagulation inhibitor; LACI (TFPI LACI TFPI1)
Function:
- inhibits factor X (factor Xa) directly
- inhibits factor VIIa/tissue factor activity (factor Xa- dependent), presumably by forming a quaternary factor Xa/LACI/factor VIIa/TF complex
- has antithrombotic action
- can associate with lipoproteins in plasma
Structure:
- O-glycosylated
- contains 3 BPTI/Kunitz inhibitor domains
- 1st domain interacts with factor VIIa & TF
- 2nd domain interacts with factor Xa
Compartment: secreted
Alternative splicing: named isoforms=2
Expression: mostly in endothelial cells
General
glycoprotein
serine protease inhibitor; serpin
Properties
SIZE: entity length = 304 aa
MW = 35 kD
MOTIF: signal sequence {1-28}
Thr glycosylation site {T42}
BPTI/Kunitz inhibitor 1 {54-104}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C104}
cysteine residue {C63}
MODIFICATION: cysteine residue {C87}
peptide motif {64-65}
cysteine residue {C79}
MODIFICATION: cysteine residue {C100}
cysteine residue {C87}
MODIFICATION: cysteine residue {C63}
cysteine residue {C100}
MODIFICATION: cysteine residue {C79}
cysteine residue {C104}
MODIFICATION: cysteine residue {C54}
BPTI/Kunitz inhibitor 2 {125-175}
MOTIF: cysteine residue {C125}
MODIFICATION: cysteine residue {C175}
cysteine residue {C134}
MODIFICATION: cysteine residue {C158}
peptide motif {135-136}
N-glycosylation site {N145}
cysteine residue {C150}
MODIFICATION: cysteine residue {C171}
cysteine residue {C158}
MODIFICATION: cysteine residue {C134}
cysteine residue {C171}
MODIFICATION: cysteine residue {C150}
cysteine residue {C175}
MODIFICATION: cysteine residue {C125}
N-glycosylation site {N195}
Ser glycosylation site {S202}
Thr glycosylation site {T203}
BPTI/Kunitz inhibitor 3 {217-267}
MOTIF: cysteine residue {C217}
MODIFICATION: cysteine residue {C267}
cysteine residue {C226}
MODIFICATION: cysteine residue {C250}
peptide motif {227-228}
cysteine residue {C242}
MODIFICATION: cysteine residue {C263}
cysteine residue {C250}
MODIFICATION: cysteine residue {C226}
asparagine residue {256}
cysteine residue {C263}
MODIFICATION: cysteine residue {C242}
cysteine residue {C267}
MODIFICATION: cysteine residue {C217}
INHIBITS: serine protease
Database Correlations
OMIM 152310
UniProt P10646
Pfam PF00014
Entrez Gene 7035
Kegg hsa:7035
References
- UniProt :accession P10646
- Wikipedia; Note: TFPI entry
http://en.wikipedia.org/wiki/TFPI
- SeattleSNPs
http://pga.gs.washington.edu/data/tfpi/