TIR domain-containing adapter molecule 1 (TICAM-1; proline-rich, vinculin & TIR domain-containing protein B; Toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; TIR domain-containing adapter protein inducing IFN-beta; NF-kappa-B-activating protein 502H; TICAM1; PRVTIRB; TRIF)

Function: - role in innate immunity against invading pathogens - adapter used by TLR3 & TLR4 (through TICAM2) to mediate NF-kappa-B & interferon-regulatory factor (IRF) activation, & to induce apoptosis - ligand binding to these receptors results in TRIF recruitment through its TIR domain - distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 & RIPK1, which in turn, lead to the activation of transcription factors IRF3 & IRF7, NF-kappa-B & FADD respectively - phosphorylated by TBK1 - interacts with the TIR domain of TLR3 - interacts with AZI2, TBK1, IRF3 & IRF7 - interacts with TRAF6 - interacts with TICAM2 in TLR4 recruitment - interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF & IFNB1 activation - interacts with IKBKB & IKBKE - interaction with SARM1 - blocks TICAM1-dependent transcription factor activation - interacts with TRAF3 (putative) Structure: - homodimer (probable) - N-terminal region is essential for activation of the IFNB promoter activity - contains 1 TIR domain Expression: - ubiquitously expressed - higher levels in liver

Properties

SIZE: entity length = 712 aa MW = 76 kD MOTIF: TRAF6-binding {84-91} proline-rich region SITE: 213-371 MOTIF: proline residue (SEVERAL) TRAF6-binding {248-255} TRAF6-binding {299-309} TIR domain {390-460} Sufficient to induce apoptosis {512-712} MOTIF: proline-rich region SITE: 614-678 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 607601 UniProt Q8IUC6

References

UniProt :accession Q8IUC6