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tirbanibulin (Klisyri)
Indecations:
- treatment of actinic keratosis on the face or scalp
Dosage:
- 1% once daily for 3 or 5 days
1% topical ointment
Mechanism of action:
- mitotic inhibitor
- inhibits tubulin polymerization & Src kinase signalling
General
antineoplastic agent (chemotherapeutic agent)
topical agent
References
- RxNorm
- Wikipedia: Tirbanibulin
https://en.wikipedia.org/wiki/Tirbanibulin
- Blauvelt A, Kempers S, Lain E et al
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis.
N Engl J Med 2021; 384:512-520. Feb 11
PMID: 33567191
https://www.nejm.org/doi/full/10.1056/NEJMoa2024040